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Purification + QC

Protein Core

The VIB Protein Core has more than 20 years of experience in DSP. The protein purifications are performed on 8 chromatographic instruments. All of them are installed at 4°C to avoid proteolytic degradation during purification.

The quality of a recombinant protein is a very important aspect. Not only the purity and identity (shown on SDS-PAGE and western blot respectively) are measured, but also additional physico-chemical characteristics. The VIB Protein Core invested in the SEC/UV/RI/ MALS technology for accurate molecular weight determinations of monomers or multimers in solution after separation on size exclusion chromatography. The UV and RI detector help in quantification of the purified protein.